Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report - Summary - MDSpire

Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report

  • By

  • Haini He

  • Min Peng

  • Xiaoliang Liu

  • Jiao Chen

  • Li Ma

  • June 17, 2026

  • 0 min

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Objective:

To report a rare case of a severe disulfiram-like reaction in a child due to accidental alcohol consumption while being treated with cefoperazone-sulbactam.

Approach:
    Key Findings:
    • The child experienced a severe disulfiram-like reaction after accidental alcohol ingestion.
    • Symptoms included hypotension and shock.
    • The child fully recovered and was discharged without sequelae.
    Interpretation:

    The case illustrates the potential for severe disulfiram-like reactions in pediatric patients treated with cefoperazone-sulbactam, especially following alcohol exposure.

    Limitations:
    • Definitive diagnosis was limited by the lack of objective alcohol quantification.
    • A hypersensitivity reaction could not be completely excluded.
    Conclusion:

    Clinicians should be vigilant for disulfiram-like reactions in children receiving cefoperazone-sulbactam and educate caregivers about avoiding alcohol.

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