To evaluate the performance of a novel Optoelectronic Imaging Tracing System (OITS) in diagnosing high-grade cervical intraepithelial neoplasia and to compare its effectiveness with existing methods, including HPV genotyping, liquid-based cytology (LBC), and colposcopy.
Key Findings:
OITS demonstrated the highest diagnostic accuracy for CIN2+ detection with an AUC of 0.798.
Sensitivity of OITS was 97.6% and specificity was 62.0%.
OITS maintained sensitivity above 93% across stratified subgroups defined by HPV status, cytology, and colposcopic impression, and showed strong performance for CIN3+ detection.
Interpretation:
OITS shows excellent and stable performance in identifying high-grade cervical lesions, suggesting it may serve as an effective adjunct or alternative triage tool.
Limitations:
The study was conducted in a single center, which may limit generalizability.
Further studies are needed to validate findings in diverse populations to ensure broader applicability.
Conclusion:
OITS may optimize cervical cancer screening and referral strategies due to its high sensitivity and objective assessment capabilities, potentially improving patient outcomes.
More than 80% of women who were partially up to date reported a wellness visit in the prior year, suggesting missed opportunities for screening engagement in primary care.
