Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth - Summary - MDSpire

Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

  • By

  • Francesca Di Candia

  • Francesco Maria Rosanio

  • Roberto Franceschi

  • Alessandro Fierro

  • Riccardo Bonfanti

  • Francesca Cardella

  • Valentino Cherubini

  • Giuseppe D’Annunzio

  • Barbara Felappi

  • Dario Iafusco

  • Brunella Iovane

  • Claudio Maffeis

  • Giulio Maltoni

  • Francesca Olivieri

  • Gabriele Olivieri

  • Barbara Piccini

  • Elvira Piccinno

  • Barbara Predieri

  • Ivana Rabbone

  • Maria Rossella Ricciardi

  • Giuseppina Salzano

  • Riccardo Schiaffini

  • Gianluca Tornese

  • Angela Zanfardino

  • Marco Marigliano

  • Riccardo Troncone

  • Riccardo Pertile

  • Luigi Greco

  • Renata Auricchio

  • Enza Mozzillo

  • ISPED Diabetes Study Group Collaborators

  • Francesco Gallo

  • Caterina Grosso

  • Carlo Ripoli

  • Fiorella De Berardinis

  • Susanna Coccoli

  • Valentina Tiberi

  • Sonia Toni

  • Maurizio Delvecchio

  • Rosanna Roppolo

  • Fortunato Lombardo

  • Stefano Passanisi

  • Bruno Bombaci

  • Alberto Casertano

  • Nicola Minuto

  • Marta Bassi

  • Evelina Maines

  • Silvia Savastio

  • Elena Inzaghi

  • Andrea Rigamonti

  • Giulio Frontino

  • Patrizia Bruzzi

  • Claudia Piona

  • November 4, 2025

  • 0 min

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Objective:

To correlate anti-TTG IgA titer, HbA1c at celiac disease diagnosis, and Marsh grade in children and adolescents with type 1 diabetes, emphasizing their interrelationships.

Key Findings:
  • HbA1c at celiac disease diagnosis was positively correlated with fold-anti-TTG IgA (Spearman r = 0.14, P = .0047).
  • Optimal anti-TTG IgA cutoff for sparing biopsy was determined to be 11 times the upper limit of normal.
  • T1D-CD individuals exhibited a higher prevalence of autoimmune comorbidities compared to T1D-only individuals (P < .001).
Interpretation:

Worse glucometabolic control in T1D-CD is associated with increased anti-TTG IgA levels and more severe mucosal damage, indicating the need for careful monitoring and potential adjustments in diagnostic criteria for celiac disease in clinical practice.

Limitations:
  • Retrospective design may introduce selection bias.
  • Data limited to a specific population in Italy, which may affect generalizability.
  • Potential confounding factors not accounted for in the analysis.
Conclusion:

Screening for celiac disease in youth with type 1 diabetes is crucial, especially given the higher prevalence of autoimmune comorbidities in those diagnosed with celiac disease before or concomitantly with type 1 diabetes. Specific recommendations for screening frequency should be considered.

Original Source(s)

Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

  • by Francesca Di Candia, Francesco Maria Rosanio, Roberto Franceschi, Alessandro Fierro, Riccardo Bonfanti, Francesca Cardella, Valentino Cherubini, Giuseppe D’Annunzio, Barbara Felappi, Dario Iafusco, Brunella Iovane, Claudio Maffeis, Giulio Maltoni, Francesca Olivieri, Gabriele Olivieri, Barbara Piccini, Elvira Piccinno, Barbara Predieri, Ivana Rabbone, Maria Rossella Ricciardi, Giuseppina Salzano, Riccardo Schiaffini, Gianluca Tornese, Angela Zanfardino, Marco Marigliano, Riccardo Troncone, Riccardo Pertile, Luigi Greco, Renata Auricchio, Enza Mozzillo, ISPED Diabetes Study Group Collaborators, Francesco Gallo, Caterina Grosso, Carlo Ripoli, Fiorella De Berardinis, Susanna Coccoli, Valentina Tiberi, Sonia Toni, Maurizio Delvecchio, Rosanna Roppolo, Fortunato Lombardo, Stefano Passanisi, Bruno Bombaci, Alberto Casertano, Nicola Minuto, Marta Bassi, Evelina Maines, Silvia Savastio, Elena Inzaghi, Andrea Rigamonti, Giulio Frontino, Patrizia Bruzzi, Claudia Piona

  • November 4, 2025

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