Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator - Summary - MDSpire

Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator

  • By

  • Lili M. Flad

  • Tanja Weißer

  • Jonas Liedl

  • Felix Gard

  • Agnese Petrera

  • Christine von Toerne

  • Stefanie M. Hauck

  • Cornelia A. Deeg

  • Kristina J. H. Kleinwort

  • June 10, 2026

  • 0 min

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Objective:

To investigate the underlying mechanisms of the inhibitory effect of A1 and A2 cow's milk on human peripheral blood mononuclear cells (PBMC).

Approach:
    Key Findings:
    • HWFs of both A1 and A2 milk exert an inhibitory effect on human PBMC.
    • Target of Myb protein 1 (TOM1) was significantly increased in the supernatant proteomes after co-incubation with HWFs.
    Interpretation:

    Limitations:
    • The biological replication at the milk-source level is effectively n = 1 per genotype.
    • Further studies are needed to confirm the role of TOM1 in vivo.
    Conclusion:

Original Source(s)

Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator

  • by Lili M. Flad, Tanja Weißer, Jonas Liedl, Felix Gard, Agnese Petrera, Christine von Toerne, Stefanie M. Hauck, Cornelia A. Deeg, Kristina J. H. Kleinwort

  • June 10, 2026

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