A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes - Summary - MDSpire

A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes

  • By

  • Dan Xiong

  • Yuanfang Jiang

  • Zhengxia Yu

  • Yaqin Zhong

  • Ke Peng

  • Xianglong Xia

  • Youqi Zhang

  • Lijun Liu

  • Weixia Peng

  • June 15, 2026

  • 0 min

Share

Objective:

To examine the disparities in 25-hydroxyvitamin D (25OH-vitD) levels and thyroid function between patients with type 2 diabetic foot (DF) and those with type 2 diabetes (T2DM), and to evaluate the predictive value of 25OH-vitD combined with thyroid function for DF and its impact on amputation.

Approach:
    Key Findings:
    • DF patients had significantly lower serum 25OH-vitD and FT3 levels compared to T2DM patients.
    • The deficiency group of 25OH-vitD (<20 ng/mL) had a higher risk of DF (OR = 3.539).
    • FT3 was identified as an independent protective factor (OR = 0.493).
    • ROC analysis showed AUC for combined predicted probability was 0.701.
    • ESS group had lower 25OH-vitD levels and higher amputation rates compared to the euthyroid group.
    Interpretation:

    Remove this section.

    Limitations:
    • The study is retrospective and may have selection bias.
    • Sample size is limited to 158 patients.
    Conclusion:

    Revise to focus solely on findings without implications.

Original Source(s)

A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes

  • by Dan Xiong, Yuanfang Jiang, Zhengxia Yu, Yaqin Zhong, Ke Peng, Xianglong Xia, Youqi Zhang, Lijun Liu, Weixia Peng

  • June 15, 2026

Related Content

Association of Serum and Aqueous Humor Levels of miR-199a-3p and FN1 with the Severity of Type 2 Diabetic Retinopathy in a Chinese Cohort

Retinal Imaging Model Aids CAD Detection

Fundus-based model showed moderate-to-good accuracy and improved performance when combined with clinical risk factors in a high-risk cohort

Diabetes Mellitus Coding in Retina

Age-related macular degeneration (AMD) is among the most common retinal diagnoses. Although the clinical features of the disease are well known, ICD-10 coding can be confusing if details such as stage, activity, and laterality are not clearly documented. Incomplete documentation may prompt questions about the medical necessity of diagnostic tests or intravitreal injections. This Q&A addresses common sources of confusion and offers practical guidance to support clear, accurate documentation.