Influence of Sex, Gender, and Sociodemographic Variables on Recurrent Prescription Refills for Chronic Pain: Findings from a Prescription Claims Analysis - Summary - MDSpire

Influence of Sex, Gender, and Sociodemographic Variables on Recurrent Prescription Refills for Chronic Pain: Findings from a Prescription Claims Analysis

  • By

  • Marimée Godbout-Parent

  • Nancy Julien

  • Hermine Lore Nguena Nguefack

  • M. Gabrielle Pagé

  • Line Guénette

  • Lucie Blais

  • Nancy Ménard

  • Sylvie Beaudoin

  • Anaïs Lacasse

  • April 22, 2026

  • 0 min

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Objective:

To examine how sex, gender, and sociodemographic factors are associated with repeated prescription refills of pain medications among individuals with chronic pain.

Key Findings:
  • Antidepressants (48%), anticonvulsants (35%), opioids (19%), and NSAIDs (18%) were the most commonly prescribed medications, with significant differences noted between subgroups.
  • Women with private drug insurance had lower odds of repeated opioid refills (aOR: 0.38; 95% CI: 0.15–0.95) compared to their male counterparts.
  • Unemployed older men had lower odds of repeated antidepressant refills (aOR: 0.45; 95% CI: 0.24–0.87) compared to unemployed women.
Interpretation:

Sex, gender, and intersecting sociodemographic factors significantly influence prescription refill patterns for chronic pain medications.

Limitations:
  • The study is limited to individuals with chronic pain and may not generalize to other populations.
  • Data is based on self-reports and prescription claims, which may not capture all medication use and could introduce bias.
Conclusion:

The findings underscore the need for an equity-oriented approach in chronic pain management, highlighting how sex, gender, and sociodemographic factors significantly influence medication use.

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