Lutein Supplementation May Improve Outcomes in Early AMD - Summary - MDSpire
From the Journals

Lutein Supplementation May Improve Outcomes in Early AMD

Meta-analysis found statistically significant improvements, with clearest benefits in early-stage disease

  • By

  • Andrea Surnit

  • May 5, 2026

  • 3 min

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A systematic review and meta-analysis revealed that lutein supplementation enhances macular pigment optical density (MPOD) and best-corrected visual acuity (BCVA) in early-stage age-related macular degeneration (AMD). The analysis of nine randomized controlled trials, encompassing 860 participants, showed significant improvements in MPOD and BCVA with lutein doses ranging from 2 to 20 mg/day. Subgroup analyses indicated that benefits were notable in early-stage AMD but not in later stages. Despite promising results, the clinical significance for BCVA changes remains uncertain, and further studies are needed to assess long-term effects.

Original Source(s)

Lutein Supplementation May Improve Outcomes in Early AMD

  • by Andrea Surnit

  • May 5, 2026

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