Association between Helicobacter pylori infection and colonic diverticulosis: a retrospective observational study in an asymptomatic Austrian endoscopy-based screening cohort - Summary - MDSpire
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Link Between Helicobacter pylori Infection and Colonic Diverticulosis: A Retrospective Study in an Asymptomatic Austrian Cohort Undergoing Endoscopy Screening
To investigate whether Helicobacter pylori (HP) infection is associated with colonic diverticulosis in an asymptomatic Austrian screening cohort.
Approach:
Study Design: Retrospective observational study of 5646 asymptomatic adults undergoing screening colonoscopy with concurrent oesophagogastroduodenoscopy from 2007 to 2020.
Data Collection: Diverticulosis classified endoscopically; HP status determined histologically from gastric biopsies.
Statistical Analysis: Multivariable logistic regression adjusted for metabolic, sociodemographic, and lifestyle factors.
Key Findings:
Diverticulosis was present in 37% of participants and HP infection in 19%.
No association found between HP infection and diverticulosis in univariable (OR 1.01, p=0.935) or fully adjusted analysis (OR 0.86, p=0.078).
Subgroup analyses showed consistent null results across diverticular distribution and risk factors.
In a longitudinal subset, diverticulosis prevalence at follow-up did not differ by baseline HP status (63.9% vs 62.1%; p=0.749).
Interpretation:
HP infection was not associated with colonic diverticulosis across subtypes or risk strata.
Limitations:
The study is retrospective and conducted in a single center, which may limit generalizability.
The population was asymptomatic, which may not reflect the broader population with diverticulosis.
Conclusion:
HP infection may be regarded as a potential confounder or marker of broader host, socioeconomic, or healthcare-related factors in future studies.
by Andreas Völkerer, Sarah Wernly, Georg Semmler, Maria Flamm, Mathias Ausserwinkler, Jutta Horejs-Hoeck, Anabel Berger, Hannah Hofer, Elmar Aigner, Christian Datz, Bernhard Wernly
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