Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis - Summary - MDSpire

Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis

  • By

  • Akram Alnounou

  • Henry Zou

  • Madison C. Laird

  • Sophie Numbers

  • Christopher Visak

  • Sage Bilsland

  • Neil Hughes

  • Eric Martin Sieloff

  • April 17, 2026

Share

Objective:

To report a case of autoimmune hemolytic anemia and hepatitis as complications of Epstein-Barr virus infection in a previously healthy young adult, highlighting its significance in clinical practice.

Key Findings:
  • Positive direct antiglobulin test for IgG, negative for C3d, indicating warm autoimmune hemolytic anemia.
  • Elevated liver enzymes and bilirubin levels consistent with hepatitis, highlighting the hepatic involvement in EBV infection.
  • Clinical improvement observed without progression to hepatic failure, underscoring the effectiveness of conservative management.
Interpretation:

This case highlights the potential for EBV to cause atypical hepatic presentations and overlapping autoimmune complications, emphasizing the need for careful diagnosis and management to improve patient outcomes.

Limitations:
  • The case is based on a single patient, limiting generalizability and potential biases in case reporting.
  • Follow-up data on long-term outcomes post-discharge are not provided, which could inform future management strategies.
Conclusion:

Recognizing and managing EBV-related complications such as AIHA and hepatitis is crucial, particularly in previously healthy individuals, to enhance awareness among clinicians.

Original Source(s)

Related Content