Mobile cognitive testing captures divergent longitudinal trajectories of verbal learning in adults with and without HIV - Summary - MDSpire

Mobile cognitive testing captures divergent longitudinal trajectories of verbal learning in adults with and without HIV

  • By

  • Alena Stasenko

  • Laura M. Campbell

  • Anne Heaton

  • Emily W. Paolillo

  • David J. Moore

  • Robert K. Heaton

  • Colin A. Depp

  • Amy Pinkham

  • Robert A. Ackerman

  • Philip D. Harvey

  • Raeanne C. Moore

  • June 16, 2026

  • 0 min

Share

Objective:

To evaluate changes in mobile Verbal Learning Test (mVLT) performance over time in people living with HIV (PWH) compared to HIV-negative controls, and to assess the impact of age and other factors on cognitive trajectories.

Key Findings:
  • Aggregate mean mVLT performance improved over time among controls, but not among PWH.
  • Longitudinal trajectories on the standard Hopkins Verbal Learning Test-Revised did not differ by group.
  • Age moderated mVLT trajectories, with worse outcomes in older PWH.
  • Worse mVLT trajectories in PWH were associated with higher cerebrovascular risk, lower social functioning, and poorer baseline global learning performance.
Interpretation:

Limitations:
  • Small sample size limits generalizability.
  • Follow-up duration varied among participants (12–46 months).
Conclusion:

Original Source(s)

Mobile cognitive testing captures divergent longitudinal trajectories of verbal learning in adults with and without HIV

  • by Alena Stasenko, Laura M. Campbell, Anne Heaton, Emily W. Paolillo, David J. Moore, Robert K. Heaton, Colin A. Depp, Amy Pinkham, Robert A. Ackerman, Philip D. Harvey, Raeanne C. Moore

  • June 16, 2026

Related Content

A federated digital twin reveals cytomegalovirus reactivation impairs CAR-T cell therapy via IL-15-mediated cytokine competition in B-Cell lymphoma

Effectiveness of digital health interventions on antiretroviral therapy adherence among people living with HIV in India: A systematic review with an RCT-only meta-analysis

Editorial: New insights on B cell development in poultry