Perioperative management of anti–TIF1-γ dermatomyositis in a patient with breast cancer: a case report - Summary - MDSpire

Perioperative management of anti–TIF1-γ dermatomyositis in a patient with breast cancer: a case report

  • By

  • YaQian Li

  • YuTing Wang

  • Gang Chen

  • July 8, 2026

  • 0 min

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Objective:

To report the perioperative anesthetic management of a patient with TIF1-γ antibody-positive dermatomyositis complicated by breast cancer.

Approach:
  • Case Presentation: A 47-year-old woman with TIF1-γ antibody-positive dermatomyositis and breast cancer underwent a modified radical mastectomy after stabilization of her condition.
  • Pre-operative Anesthesia Evaluation: Comprehensive evaluation included pulmonary function tests, echocardiography, and assessments for dysphagia and hypercoagulability.
  • Intraoperative Anesthesia Management: Standard monitoring was employed, and specific anesthetic agents were chosen to mitigate risks associated with the patient's condition.
Key Findings:
  • The patient exhibited classic cutaneous manifestations, proximal myopathy, and oropharyngeal dysphagia.
  • Comprehensive pre-operative assessment and individualized anesthetic management were crucial for a favorable outcome.
  • TIF1-γ antibody-positive dermatomyositis is associated with increased perioperative anesthetic risk due to multisystem involvement.
Interpretation:

This case highlights the marked clinical heterogeneity of dermatomyositis subtypes and the corresponding differences in perioperative anesthetic risk.

Limitations:
  • The study is based on a single case report, limiting generalizability.
  • Variability in patient responses to anesthetic management may not be applicable to all patients with similar conditions.
Conclusion:

Thorough pre-operative evaluation and individualized anesthetic management are essential for optimizing perioperative outcomes.

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