Objective:

To examine health-related quality of life (HRQoL) and its biopsychosocial determinants in Chinese patients with neuromyelitis optica spectrum disorder (NMOSD).

Approach:

Key Findings:

• The cohort had a median age of 37, with 85.2% being female.
• Significantly reduced median PCS (55.5) and MCS (51.0) were observed, with role-physical (25.0) and role-emotional (33.3) being the most impaired.
• Older age, depressive symptoms, social avoidance, and poor sleep were independently associated with worse PCS.
• Depressive symptoms, social avoidance, poor sleep quality, and lower resilience were significant factors for MCS.

Interpretation:

Psychosocial factors critically influence HRQoL in Chinese NMOSD patients.

Conclusion:

Multidimensional, culturally sensitive interventions targeting mental health, sleep, and social functioning may improve patient outcomes.

Attribution Notice

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