Retraction Notice: The Role of CD276 in Promoting Sunitinib Resistance in Clear Cell Renal Cell Carcinoma Through DNA Damage Repair and FAK-MAPK Pathway Activation - Summary - MDSpire

Retraction Notice: The Role of CD276 in Promoting Sunitinib Resistance in Clear Cell Renal Cell Carcinoma Through DNA Damage Repair and FAK-MAPK Pathway Activation

  • By

  • Zhi-yu Zhang

  • Jian-hao Xu

  • Jiang-lei Zhang

  • Yu-xin Lin

  • Jun Ou-Yang

  • January 12, 2026

  • 0 min

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Objective:

To investigate the specific role of CD276 in promoting sunitinib resistance in clear cell renal cell carcinoma.

Key Findings:
  • The article was retracted due to issues with data integrity, including a request for correction regarding a duplicated image in Fig. 3c.
  • Discrepancies were found in the western blot scans and expected molecular weights.
  • The authors could not provide adequate explanations or original raw data.
Interpretation:

The retraction indicates a significant lack of confidence in the validity of the research findings, raising concerns about data integrity in the field.

Limitations:
  • Inability to verify the original data, which undermines the study's conclusions.
  • Concerns over image duplication in published figures, affecting the credibility of the results.
Conclusion:

The article has been retracted by the editors, and all authors have agreed to this decision, reflecting a consensus on the issues identified.

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