Clinical correlates of lipoprotein (a) and apolipoprotein B levels in patients with dyslipidemia and cardiovascular disease - Summary - MDSpire

Clinical correlates of lipoprotein (a) and apolipoprotein B levels in patients with dyslipidemia and cardiovascular disease

  • By

  • Luana Alexandrescu

  • Daria Maria Alexandrescu

  • Ionut Tiberiu Tofolean

  • Doina Ecaterina Tofolean

  • Steliana Pindichi

  • Eugen Dumitru

  • Bogdan Campineanu

  • Cristina Aftenie

  • Andreea Nelson Twakor

  • Alexandra Herlo

  • Elena Rusu

  • Diana Raluca Baicu

  • Madalina Ilie

  • Filip-Vasile Berariu

  • Laura Maria Condur

  • July 9, 2026

  • 0 min

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Objective:

To evaluate the clinical, metabolic, and biochemical correlates of Lp(a) and ApoB levels in patients with dyslipidemia and cardiovascular disease.

Approach:
  • Study Design: Cross-sectional observational analysis of 153 adults evaluated for cardiometabolic risk.
  • Data Collection: Assessment of anthropometric, biochemical, and inflammatory parameters.
  • Analysis Methods: Correlation analyses and decision tree regression to explore associations and variability.
Key Findings:
  • Mean age of participants was 57.9 ± 12.3 years; 79.1% had dyslipidemia and 75.2% had established cardiovascular disease.
  • Mean Lp(a) concentration was 30.14 ± 31.50 mg/dL; mean ApoB was 119.87 ± 36.01 mg/dL.
  • ApoB showed significant correlations with total cholesterol (r = 0.49, p < 0.001), triglycerides (r = 0.46, p < 0.001), and LDL-C (r = 0.26, p < 0.01).
  • GGT, creatinine, and uric acid were identified as factors influencing Lp(a) variability.
Interpretation:

Hepatic and renal function markers significantly modulate Lp(a) levels, while ApoB is a robust indicator of atherogenic particle load.

Limitations:
  • Single-center study may limit generalizability.
  • Cross-sectional design does not establish causation.
Conclusion:

Original Source(s)

Clinical correlates of lipoprotein (a) and apolipoprotein B levels in patients with dyslipidemia and cardiovascular disease

  • by Luana Alexandrescu, Daria Maria Alexandrescu, Ionut Tiberiu Tofolean, Doina Ecaterina Tofolean, Steliana Pindichi, Eugen Dumitru, Bogdan Campineanu, Cristina Aftenie, Andreea Nelson Twakor, Alexandra Herlo, Elena Rusu, Diana Raluca Baicu, Madalina Ilie, Filip-Vasile Berariu, Laura Maria Condur

  • July 9, 2026

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