To evaluate long-term tumor control, safety outcomes, and dose-volume associations in patients with pineal region meningiomas treated with single-fraction Gamma Knife Radiosurgery (GKRS).
Key Findings:
Local tumor control was achieved in a significant proportion of patients.
Adverse radiation effects were observed but were generally manageable.
The study represents one of the largest cohorts with long-term follow-up for GKRS in this tumor location.
Interpretation:
Single-fraction GKRS is a viable treatment option for pineal region meningiomas, offering good tumor control with acceptable safety profiles.
Limitations:
Retrospective design may introduce bias.
Limited generalizability due to single-center data.
Lack of advanced imaging for comprehensive assessment of adverse effects.
Conclusion:
GKRS is an effective and safe treatment for pineal region meningiomas, providing a minimally invasive alternative to traditional surgery.
