To investigate the influence of maternal fasting plasma glucose (mFPG) level measured before 24 gestational weeks on developmental delay in children at age two.
Key Findings:
5.2% of participants had mFPG levels ≥95 mg/dL.
15.1% of children exhibited developmental delays at age two.
No association was found between continuous mFPG levels and developmental delay across the five domains.
mFPG levels ≤70 mg/dL were linked to developmental delays compared to levels 71-94 mg/dL.
No significant association was observed between mFPG levels ≤70 mg/dL and ≥95 mg/dL with developmental delays.
Interpretation:
Early gestational mFPG levels do not appear to increase the risk of developmental delays in children at age two, indicating no significant association.
Limitations:
Study limited to a specific population in Japan, which may affect generalizability to other populations.
Exclusion of mothers with a history of diabetes may limit understanding of broader impacts on developmental outcomes.
Conclusion:
Maternal fasting plasma glucose levels in early gestation are not associated with an increased risk of developmental delays in children at age two.
