Etiology and Antimicrobial Resistance of Culture-Positive Infections in Ugandan Infants: A Cohort Study of 7000 Neonates and Infants - Summary - MDSpire

Etiology and Antimicrobial Resistance of Culture-Positive Infections in Ugandan Infants: A Cohort Study of 7000 Neonates and Infants

  • By

  • Hannah G Davies

  • Mary Kyohere

  • Valerie Tusubira

  • Alexander Amone

  • Amusa Wamawobe

  • Cleophas Komugisha

  • Philippa Musoke

  • Lauren Hookham

  • Pooja Ravji

  • Melanie Etti

  • Juliet Nsimire Sendagala

  • Dan R Shelley

  • Caitlin Farley

  • Merryn Voysey

  • Owen B Spiller

  • Joseph Peacock

  • Musa Sekikubo

  • Paul T Heath

  • Kirsty Le Doare

  • PROGRESS Study Author Group

  • Abdelmajid Djennad

  • Agnes Nyamaizi

  • Agnes Ssali

  • Alexander Amone

  • Amusa Wamawobe

  • Annettee Nakimuli

  • Caitlin Farley

  • Carol Nanyunja

  • Christine Najuka

  • Cleophas Komugisha

  • Dan R Shelley

  • Edward A R Portal

  • Ellie Duckworth

  • Emilie Karafillakis

  • Geraldine O’Hara

  • Godfrey Matovu

  • Hannah G Davies

  • Janet Seeley

  • Joseph Peacock

  • Juliet Nsimire Sendagala

  • Katie Cowie

  • Kirsty Le Doare

  • Konstantinos Karampatsas

  • Lauren Hookham

  • Madeleine Cochet

  • Margaret Sewegaba

  • Mary Kyohere

  • Maxensia Owor

  • Melanie Etti

  • Merryn Voysey

  • Moses Musooko

  • Musa Sekikubo

  • Owen B Spiller

  • Patience Atuhaire

  • Paul T Heath

  • Philippa Musoke

  • Phiona Nalubega

  • Pooja Ravji

  • Richard Katungye

  • Ritah Namugumya

  • Rosalin Parks

  • Rose Azuba

  • Sam Kipyeko

  • Simon Beach

  • Stephen Bentley

  • Tim Old

  • Tobius Mutabazi

  • Valerie Tusubira

  • Vicki Chalker

  • March 10, 2025

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Objective:

To describe the etiology of neonatal infections, including both bacterial and viral causes, and assess antimicrobial resistance patterns in Ugandan infants.

Key Findings:
  • 7323 infants with signs or risk factors for sepsis had blood cultures collected.
  • 11% of blood cultures and 8.6% of nasopharyngeal swabs were positive for pathogens.
  • Inpatient mortality was 12.1%, with 27.7% case fatality in infants with Gram-negative bloodstream infections.
  • Escherichia coli (14.8%), Acinetobacter spp. (10.3%), and Klebsiella spp. (7.6%) were significant Gram-negative pathogens.
  • Group B Streptococcus was the predominant Gram-positive pathogen (13.5%).
  • Nearly 60% of Gram-negative pathogens showed resistance to ampicillin and gentamicin.
Interpretation:

The study highlights high levels of antimicrobial resistance and significant inpatient mortality due to neonatal sepsis in Uganda, indicating a need for updated treatment guidelines.

Limitations:
  • Limited availability of blood culture and diagnostic resources in low-resource settings.
  • Potential underreporting of viral infections due to diagnostic challenges.
Conclusion:

The findings underscore the urgent need for revised, context-specific antimicrobial treatment guidelines to address the evolving landscape of antimicrobial resistance in neonatal sepsis.

Original Source(s)

Etiology and Antimicrobial Resistance of Culture-Positive Infections in Ugandan Infants: A Cohort Study of 7000 Neonates and Infants

  • by Hannah G Davies, Mary Kyohere, Valerie Tusubira, Alexander Amone, Amusa Wamawobe, Cleophas Komugisha, Philippa Musoke, Lauren Hookham, Pooja Ravji, Melanie Etti, Juliet Nsimire Sendagala, Dan R Shelley, Caitlin Farley, Merryn Voysey, Owen B Spiller, Joseph Peacock, Musa Sekikubo, Paul T Heath, Kirsty Le Doare, PROGRESS Study Author Group, Abdelmajid Djennad, Agnes Nyamaizi, Agnes Ssali, Alexander Amone, Amusa Wamawobe, Annettee Nakimuli, Caitlin Farley, Carol Nanyunja, Christine Najuka, Cleophas Komugisha, Dan R Shelley, Edward A R Portal, Ellie Duckworth, Emilie Karafillakis, Geraldine O’Hara, Godfrey Matovu, Hannah G Davies, Janet Seeley, Joseph Peacock, Juliet Nsimire Sendagala, Katie Cowie, Kirsty Le Doare, Konstantinos Karampatsas, Lauren Hookham, Madeleine Cochet, Margaret Sewegaba, Mary Kyohere, Maxensia Owor, Melanie Etti, Merryn Voysey, Moses Musooko, Musa Sekikubo, Owen B Spiller, Patience Atuhaire, Paul T Heath, Philippa Musoke, Phiona Nalubega, Pooja Ravji, Richard Katungye, Ritah Namugumya, Rosalin Parks, Rose Azuba, Sam Kipyeko, Simon Beach, Stephen Bentley, Tim Old, Tobius Mutabazi, Valerie Tusubira, Vicki Chalker

  • March 10, 2025

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