Comparative analysis of indocyanine green and technetium-99m for sentinel lymph node localization in breast cancer – institutional experience - Summary - MDSpire
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Comparative analysis of indocyanine green and technetium-99m for sentinel lymph node localization in breast cancer – institutional experience
To assess the diagnostic performance and clinical feasibility of ICG-guided sentinel lymph node biopsy (SLNB) compared with the standard Tc-99m-nanocolloid method, focusing on detection rates and safety.
Key Findings:
ICG fluorescence achieved a sentinel node detection rate of 90.6%, compared to 97.1% for Tc-99m.
A median of 2.1 lymph nodes were excised per patient.
Metastatic node detection was 94.1% using ICG, 79.4% with Tc-99m, and 100% with the combined approach.
No ICG-related complications or adverse events were reported.
Interpretation:
ICG fluorescence-guided SLNB is a safe, effective, and radiation-free alternative to conventional radioisotope mapping, demonstrating high detection accuracy and real-time visualization, which could significantly enhance surgical practice.
Limitations:
Small sample size may limit the interpretation of neoadjuvant results.
Single-center study may affect generalizability and introduce potential biases.
Conclusion:
ICG fluorescence-guided SLNB should be integrated into standard breast cancer surgery protocols, and further multicenter studies are essential to validate long-term outcomes.
