Objective:

To explore the dual role of TREM2 in fibrosis across different organs and its implications for macrophage polarization and fibrosis progression.

Approach:

Key Findings:

• TREM2 regulates inflammation and tissue repair, acting as an 'inflammatory brake' in macrophages.
• The role of TREM2 in fibrosis varies by organ; it can have effects in the liver but may promote fibrosis in the lungs.
• TREM2 influences macrophage functional polarization, immunometabolic reprogramming, and multicellular communication in the fibrotic microenvironment.

Interpretation:

Limitations:

• The review is limited to studies published in English and may not encompass all relevant literature.
• Focus on recent studies may overlook earlier foundational research.

Conclusion:

Attribution Notice

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