The value of speckle tracking echocardiography in early identification of subclinical cardiac involvement in patients with multiple myeloma: a pilot retrospective study - Summary - MDSpire

The value of speckle tracking echocardiography in early identification of subclinical cardiac involvement in patients with multiple myeloma: a pilot retrospective study

  • By

  • ZhengShuo Jin

  • Xuehan Mao

  • Fan Yu

  • Yanying Wang

  • Bianhong Wang

  • Jingxian Li

  • Jiao Li

  • Lihong Li

  • Yuehua Huang

  • June 26, 2026

  • 0 min

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Objective:

To explore the association between Global Longitudinal Strain (GLS) and clinically defined cardiac involvement in multiple myeloma (MM) patients.

Approach:
  • GLS Comparison: GLS was compared between the two groups using ROC analysis to assess its diagnostic performance.
Key Findings:
  • Absolute GLS was significantly lower in the CI group (median 9.6% vs. 16.9%, p = 0.007).
  • GLS showed an area under the ROC curve of 0.980 (95% CI: 0.92–1.00) for identifying clinical cardiac involvement.
  • An optimal GLS cut-off of -16% provided a sensitivity of 100% and specificity of 53.3%.
Interpretation:

Limitations:
  • Small sample size limits the generalizability of results.
  • Lack of gold-standard confirmation for cardiac involvement.
Conclusion:

The findings require external validation in larger, prospective, multi-center cohorts.

Original Source(s)

The value of speckle tracking echocardiography in early identification of subclinical cardiac involvement in patients with multiple myeloma: a pilot retrospective study

  • by ZhengShuo Jin, Xuehan Mao, Fan Yu, Yanying Wang, Bianhong Wang, Jingxian Li, Jiao Li, Lihong Li, Yuehua Huang

  • June 26, 2026

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