Assessment of differences in immune responses to albumin compared with crystalloids for resuscitation in sepsis - Summary - MDSpire

Assessment of differences in immune responses to albumin compared with crystalloids for resuscitation in sepsis

  • By

  • John Cafferkey

  • Jennifer Rynne

  • Andrew Ferguson

  • Julia Grahamslaw

  • Peter Smith

  • Ewan A. M. Pow

  • Katherine Oatey

  • Daniel Horner

  • Alasdair R. Corfield

  • Alasdair Gray

  • Manu Shankar-Hari

  • June 18, 2026

  • 0 min

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Objective:

To describe differences between immune cell subsets, cytokines, and whole blood transcriptome between treatment groups of 5% Human Albumin Solution (5% HAS) and balanced crystalloid in sepsis resuscitation.

Approach:
    Key Findings:
    • Monocytes and CD4 + T-cells were higher in the crystalloid group at both T2 and T3.
    • The crystalloid group had significantly lower IFN-gamma at T3 compared to the 5% HAS group.
    • 5% HAS group showed significant decreases in CCL20 and CCL4 over time.
    • Differentially expressed genes related to plasma cells and immunoglobulins were expressed less in the crystalloid group compared to 5% HAS.
    Interpretation:

    Limitations:
    • Small sample size.
    • Low incidence of outcomes of interest.
    • Intervention window limited to 6 hours.
    Conclusion:

    No significant differences were found between 5% HAS and crystalloid in terms of immune response during the first-line resuscitation.

Original Source(s)

Assessment of differences in immune responses to albumin compared with crystalloids for resuscitation in sepsis

  • by John Cafferkey, Jennifer Rynne, Andrew Ferguson, Julia Grahamslaw, Peter Smith, Ewan A. M. Pow, Katherine Oatey, Daniel Horner, Alasdair R. Corfield, Alasdair Gray, Manu Shankar-Hari

  • June 18, 2026

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