The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI - Summary - MDSpire
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The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI
To analyze the determinants of circulating itaconate concentrations and evaluate the potential modulatory role of dietary patterns, particularly legume consumption, as well as sex-specific differences in individuals with excessive adiposity.
Key Findings:
Circulating itaconate concentrations did not differ across categories of legume intake or adherence to the Mediterranean diet.
Higher legume consumption was associated with a healthier lifestyle profile and lower adiposity, but not with circulating itaconate.
Monocyte counts were independently associated with circulating itaconate, while IL-6 showed an independent inverse association.
A significant interaction between itaconate and sex was identified for monocyte counts, with an inverse association observed in men but not in women.
Interpretation:
Limitations:
The study does not establish causation between legume consumption and circulating itaconate levels.
The sample may not be representative of the general population due to specific inclusion criteria.
Conclusion:
The findings highlight notable sex-specific immune responses, underscoring the importance of considering biological sex in understanding variations in immune function.
by Amanda Cuevas-Sierra, Andrea Higuera-Gómez, Begoña de Cuevillas, Gabriela Paula-Buestan, María Martínez-Urbistondo, Raquel Castejón, J. Antonio Vargas, José Moisés Laparra, J. Alfredo Martínez
