Objective:

To evaluate the effectiveness of SIRI, NLR, dNLR, and SII in predicting the prognosis of acute diverticulitis, highlighting their potential clinical significance.

Key Findings:

• Out of 286 patients, 82 met inclusion criteria; 56 had uncomplicated and 26 had complicated diverticulitis, indicating a significant prevalence of complications.
• Higher inflammatory markers (WBC, CRP, NLR, SII, dNLR, SIRI) were significantly associated with complicated diverticulitis, suggesting their role in risk stratification.
• Duration of hospital stay and rate of surgical interventions were significantly higher in complicated cases, underscoring the clinical impact of accurate classification.

Interpretation:

NLR, SII, and SIRI are effective biomarkers for assessing the severity of acute diverticulitis, aiding in clinical decision-making and potentially improving patient outcomes.

Limitations:

• Retrospective design may introduce selection bias, limiting causal inferences.
• Limited generalizability due to single-center study, suggesting the need for multi-center validation.

Conclusion:

SIRI, NLR, dNLR, and SII are promising non-invasive biomarkers for predicting the prognosis of acute diverticulitis, warranting further research to explore their utility in diverse clinical settings.