Sex-specific co-occurrence patterns of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease among patients with colorectal cancer: a retrospective EMR-based series - Summary - MDSpire
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Sex-specific co-occurrence patterns of Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease among patients with colorectal cancer: a retrospective EMR-based series
To explore the sex-specific prevalence and co-occurrence patterns of Type 2 Diabetes Mellitus (T2DM) and Non-Alcoholic Fatty Liver Disease (NAFLD) among colorectal cancer (CRC) patients using electronic medical records.
Approach:
Study Design: Retrospective study involving 438 CRC patients treated at a tertiary hospital in China.
Data Collection: Diagnoses of T2DM and NAFLD were confirmed based on physician-documented records.
Statistical Analysis: Descriptive statistics and bivariate analyses were used to evaluate prevalence patterns and metabolic indicators.
Key Findings:
T2DM prevalence was 10.04% in male CRC patients and 5.92% in females.
NAFLD prevalence was 8.18% in males and 4.73% in females.
Co-occurrence of T2DM and NAFLD was rare at 0.68%.
Patients with T2DM or NAFLD exhibited distinctive metabolic abnormalities.
Interpretation:
The study highlights distinct sex-based prevalence patterns of T2DM and NAFLD in CRC patients, but the rarity of co-occurrence limits further inferential analyses.
Limitations:
Co-occurrence of T2DM and NAFLD was rare, limiting analyses.
Study conducted in a single tertiary hospital may limit generalizability.
Conclusion:
Findings emphasize the need for larger, prospective studies to better characterize metabolic comorbidity patterns in CRC from a sex-specific perspective.
by Mohammadreza Akbarian Khorasgani, Pouriya Katouzi, Melika Khalifeh Hadi, Masoumeh Amarloei, Yasaman Kianpourhafshejani, Sumaeya Sultana, Mohammed Hasan Mohammed Ahmed Al-Mlawi, Yunqing Zeng, Jiaoyang Lu
