To investigate the brain to liver glucose uptake ratio (B2LR) in patients with multiple myeloma and its correlation with disease activity, highlighting its potential significance as a prognostic indicator.
Key Findings:
The B2LR was significantly different between patients with active disease and those in remission (p < 0.05).
Higher B2LR correlated with improved progression-free survival (PFS) and overall survival (OS).
The findings suggest that the B2LR may serve as a prognostic indicator in multiple myeloma, reflecting the competition for glucose uptake between the brain and tumors, which may influence treatment outcomes.
Limitations:
The study was limited to a single center, which may affect generalizability and introduce potential biases.
Small sample size in the initial cohort may limit the robustness of findings.
Conclusion:
The B2LR could be a valuable metric for assessing disease activity and prognosis in multiple myeloma patients, warranting further investigation in larger, multicenter studies to validate these findings.
by Sarah Dingli, Paul Rothweiler, Moritz Binder, Joselle Cook, Morie A. Gertz, Suzanne Hayman, Prashant Kapoor, Taxiarchis Kourelis, Shaji K. Kumar, Mustaqeem Siddiqui, Rahma Warsame, Yi Lin, Arthur G. Erdman, David Dingli
