To synthesize evidence on the role of viral and fungal infections in nonresolving acute respiratory distress syndrome (ARDS).
Approach:
Key Findings:
Invasive pulmonary aspergillosis is common in ARDS secondary to severe viral pneumonia, with mortality rates exceeding 50%, highlighting the severity of this complication.
Interpretation:
The interplay between viral and fungal infections in ARDS underscores the urgent need for improved diagnostic and treatment strategies to effectively manage these complications.
Limitations:
Biases in observational studies and limited sample sizes in clinical trials may affect the reliability of the findings.
Conclusion:
Systematic assessment of viral reactivation in ARDS patients may be warranted, given the potential for significant clinical impact despite uncertainties in treatment efficacy.