Commentary: Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors - Summary - MDSpire
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Insights on Key Factors Influencing Post-Stroke Depression and Cognitive Decline in Survivors of Acute Stroke

  • By

  • Polona Rus Prelog

  • Matija Zupan

  • Senta Frol

  • September 14, 2026

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Objective:

To examine predictors of post-stroke depression (PSD) and cognitive impairment (PSCI) among acute stroke survivors.

Approach:
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Key Findings:
  • Right-hemisphere lesions, higher baseline PHQ-9 scores, and lower baseline MMSE scores independently predicted composite outcomes of PSD and PSCI.
  • The combined endpoint of PSD and PSCI encompasses different trajectories that may require distinct treatment approaches.
  • The use of PHQ-9 and MMSE as screening tools can identify individuals at risk for PSD and PSCI.
Interpretation:

The overlap between PSD and PSCI may indicate shared neurobiological mechanisms, but their determinants and treatment may differ.

Limitations:
  • The operationalization of PSD and PSCI through brief screening scales may affect risk stratification and clinical interpretation.
  • MMSE has limitations in detecting specific cognitive deficits in post-stroke populations.
Conclusion:

Future research should refine definitions of PSD and PSCI, explore domain-specific cognitive assessments, and model depressive and cognitive trajectories separately.

Sources:

Original Source(s)

Commentary: Identifying key predictors of post-stroke depression and cognitive impairment in acute stroke survivors

  • by Polona Rus Prelog, Matija Zupan, Senta Frol

  • September 14, 2026

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