The Relationship Between Personality Traits and Alzheimer's Disease: A Narrative Review - Summary - MDSpire

The Relationship Between Personality Traits and Alzheimer's Disease: A Narrative Review

  • By

  • Bednorz, Adam

  • Religa, Dorota

  • May 6, 2026

  • 0 min

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Objective:

To examine the relationship between personality traits and the risk of Alzheimer's disease (AD).

Key Findings:
  • High neuroticism is consistently linked to increased risk of Alzheimer's disease and cognitive decline.
  • Low conscientiousness is associated with a higher risk of cognitive decline and dementia.
  • Conscientiousness may provide a protective effect against cognitive decline.
  • Extraversion and openness have variable associations with AD, potentially offering protective roles.
  • Agreeableness shows weak and inconsistent relationships with AD risk.
  • Longitudinal studies indicate personality traits act as premorbid risk or protective factors.
Interpretation:

Personality traits significantly influence individual vulnerability to cognitive decline, suggesting their potential role in early risk identification and prevention strategies for Alzheimer's disease.

Limitations:
  • The review is based on existing literature, which may have inherent biases.
  • Cross-sectional studies may not accurately reflect the causal relationship between personality traits and AD.
Conclusion:

Understanding personality traits can aid in identifying individuals at risk for cognitive decline, emphasizing the importance of psychological factors in Alzheimer's disease.

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