Investigation of the effects of radiotherapy and chemotherapy on brain volume in cancer patients: brain tumor study - Summary - MDSpire

Investigation of the effects of radiotherapy and chemotherapy on brain volume in cancer patients: brain tumor study

  • By

  • Birgül Deniz

  • Muhammed Furkan Arpaci

  • Hıdır Pekmez

  • Gökçe Bağci Uzun

  • Feyza İnceoğlu

  • Hakan Harputluoğlu

  • February 13, 2026

  • 0 min

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Objective:

To objectively measure brain structures and tumor volumes in patients diagnosed with brain tumors before and after treatment using VolBrain and MRICloud systems, aiming to enhance treatment personalization.

Key Findings:
  • The median total radiotherapy dose was 60 Gy in 30 to 33 fractions, with a range of 56 to 68 Gy, indicating a standard treatment protocol.
  • Nineteen patients received whole brain irradiation at a dose of 40 Gy, highlighting treatment diversity.
Interpretation:

The study aims to enhance understanding of the relationship between changes in brain structures and treatment outcomes, potentially leading to individualized treatment plans based on quantitative measurements.

Limitations:
  • Exclusion of 400 patients without MRI images before or after treatment may limit the generalizability of the findings.
  • Exclusion of 30 patients without FLAIR sequence and 23 patients with severe motion artifacts may introduce bias in the analysis.
Conclusion:

Objective and quantitative measurements of brain structures may improve treatment planning and quality of life for patients with brain tumors, aligning with current trends in personalized medicine.

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