Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale - Summary - MDSpire

Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale

  • By

  • Sina Stoltefuß

  • Gabriela Leuschner

  • Tobias Veit

  • Jeremias Götschke

  • Katrin Milger

  • Teresa Kauke

  • Alexandra Lenoir

  • Nikolaus Kneidinger

  • Jürgen Behr

  • January 10, 2026

  • 0 min

Share

Objective:

To compare health-related quality of life (HRQoL) between interstitial lung disease (ILD) patients who have undergone lung transplantation (LTx) and those who have not, and to assess the impact of chronic lung allograft dysfunction (CLAD) on HRQoL in transplanted patients.

Key Findings:
  • Transplanted patients generally reported improved HRQoL compared to non-transplanted patients.
  • The presence of CLAD negatively impacted HRQoL in transplanted patients.
  • The GR-Scale effectively captured patient-reported outcomes and changes in HRQoL over time.
Interpretation:

The study highlights the importance of HRQoL as a critical outcome in ILD management, particularly in evaluating the effects of lung transplantation and the complications arising from CLAD.

Limitations:
  • The study was limited to a single center, which may affect generalizability.
  • The sample size was relatively small, impacting the statistical power of the findings.
  • The study did not include objective measures of lung function in the HRQoL analysis.
Conclusion:

The GR-Scale is a valuable tool for assessing HRQoL in ILD patients, demonstrating significant differences between transplanted and non-transplanted patients, and highlighting the detrimental effects of CLAD on quality of life.

Original Source(s)

Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale

  • by Sina Stoltefuß, Gabriela Leuschner, Tobias Veit, Jeremias Götschke, Katrin Milger, Teresa Kauke, Alexandra Lenoir, Nikolaus Kneidinger, Jürgen Behr

  • January 10, 2026

Related Content

MDA5-related juvenile dermatomyositis and interstitial lung disease: Transitioning from rapid progression to a quiescent state in three pediatric cases from South Africa, along with a literature review.

Former Smokers May Merit Later Screening

Cohort data suggest past-eligible former smokers retain competing mortality profiles similar to younger current-eligible smokers

Top 10 States for Physician-Owned Hospitals

These 10 states make it more practical for physicians to participate in hospital ownership by aligning statutory structure, corporate practice of medicine rules, and population trends.