Objective:

To systematically assess perioperative clinical safety, medium-term weight loss outcomes, multidisciplinary management challenges, and the clinical applicability of laparoscopic sleeve gastrectomy (LSG) in adults with Prader-Willi syndrome (PWS) and super-morbid obesity, with the aim of identifying appropriate candidates for surgical intervention and establishing standardized perioperative management strategies.

Approach:

Key Findings:

• Short-term postoperative recovery was uneventful.
• Long-term weight reduction outcomes and the risk of postoperative complications remain uncertain.
• LSG was associated with modest weight reduction in patients with PWS, but significant postoperative management challenges persisted, necessitating ongoing multidisciplinary support.

Interpretation:

LSG should not be considered a first-line intervention for patients with PWS and should be restricted to carefully selected patients following comprehensive MDT evaluation, highlighting the need for further research into individualized treatment strategies.

Limitations:

• Uncertainty regarding long-term weight reduction outcomes.
• Postoperative complications and management challenges were not fully addressed, and the lack of long-term follow-up data is a concern.

Conclusion:

Optimized perioperative behavioral management and emerging therapies may expand surgical eligibility within this patient population, underscoring the importance of individualized treatment strategies.

Attribution Notice

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