Assessment of Safety and Effectiveness of Combined Platelet-Rich Plasma and Hyaluronic Acid Therapy for Neck Rejuvenation in Thailand: A Prospective Investigation - Summary - MDSpire

Assessment of Safety and Effectiveness of Combined Platelet-Rich Plasma and Hyaluronic Acid Therapy for Neck Rejuvenation in Thailand: A Prospective Investigation

  • By

  • Stephanie T. de Leon

  • Diandra A. Zabala

  • Noldtawat Viriyaskultorn

  • Panyapat Buranaporn

  • Woramate Bhorntarakcharoen

  • Thrit Hutachoke

  • Thanyaporn Leesanguankul

  • Teerapat Wannawittayapa

  • Wetch Tantrapongsathorn

  • Sariya Sittiwanaruk

  • Rungsima Wanitphakdeedecha

  • January 11, 2026

  • 0 min

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Objective:

To evaluate the safety and efficacy of three monthly intradermal PRP-HA injections for neck rejuvenation in adults aged 18-60 with mild-to-moderate neck aging.

Key Findings:
  • Significant improvements in skin firmness (up to 65% at 6 months), hydration, and reductions in melanin, erythema, and sebum were observed, with no severe adverse effects reported.
  • Modest outcomes were noted for skin elasticity, wrinkles, texture, and brightness.
Interpretation:

PRP-HA is a relatively safe and viable minimally invasive treatment for neck rejuvenation, though results on certain biometric parameters were variable, indicating the need for further studies to confirm efficacy.

Limitations:
  • Small sample size of 30 participants may limit the generalizability of the findings.
  • Lack of a control group for comparison restricts the ability to draw definitive conclusions.
Conclusion:

PRP-HA therapy shows promise for neck rejuvenation, warranting further controlled studies to confirm efficacy and safety, particularly in diverse populations.

Original Source(s)

Assessment of Safety and Effectiveness of Combined Platelet-Rich Plasma and Hyaluronic Acid Therapy for Neck Rejuvenation in Thailand: A Prospective Investigation

  • by Stephanie T. de Leon, Diandra A. Zabala, Noldtawat Viriyaskultorn, Panyapat Buranaporn, Woramate Bhorntarakcharoen, Thrit Hutachoke, Thanyaporn Leesanguankul, Teerapat Wannawittayapa, Wetch Tantrapongsathorn, Sariya Sittiwanaruk, Rungsima Wanitphakdeedecha

  • January 11, 2026

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