Objective:

To evaluate the efficacy of tranexamic acid in reducing postoperative recurrence rates and hematoma volume following surgical evacuation of chronic subdural hematomas.

Approach:

Key Findings:

• Chronic subdural hematoma is prevalent, particularly among older adults, with notable recurrence rates following surgical intervention.
• The administration of tranexamic acid may mitigate hyperfibrinolysis, which is associated with the re-expansion of hematomas.
• This study aims to provide evidence regarding the effectiveness of TXA in lowering revision surgery rates and reducing hematoma volume.

Interpretation:

This study aims to clarify the role of tranexamic acid in the management of chronic subdural hematomas, addressing inconsistencies found in prior research.

Limitations:

• Potential indication bias due to lack of standardized treatment protocols for TXA administration.
• Retrospective design may limit the generalizability of findings.

Conclusion:

The findings of this study may enhance the understanding of tranexamic acid's effectiveness in managing chronic subdural hematomas.

Source

Based on findings from:

Revision rate and postoperative volume development of chronic subdural hematomas after burr hole craniotomy in combination with tranexamic acid vs. surgery alone – a single-center propensity score-matched analysis

Magnus Scheer, Hanno Witte, Paulina Guenzerodt, Vanessa Beuchel, Uwe Max Mauer, Chris Schulz. Bmc Neurology, 2026.

https://link.springer.com/article/10.1186/s12883-026-05003-3

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