A Retrospective Analysis of the Surgical Efficacy for Tophi Wounds in Hainan Province - Summary - MDSpire

A Retrospective Analysis of the Surgical Efficacy for Tophi Wounds in Hainan Province

  • By

  • Xiao, Weihao

  • Ming, Xingchen

  • Huang, Yuxi

  • Li, Jiaxuan

  • Jiao, Qiqi

  • Yang, Jian

  • Zheng, Linyang

  • Zeng, Yunfu

  • Wang, Rong

  • Cheng, Shaowen

  • Bian, Yangyang

  • Yao, Jiangling

  • April 13, 2026

  • 0 min

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Objective:

To analyze perioperative data and surgical treatment outcomes in patients with gouty tophi to investigate the indications for surgical treatment.

Key Findings:
  • 130 patients included, predominantly male (99.2%) with a mean age of 58.15 years.
  • Common comorbidities: hypertension (43.85%), diabetes mellitus (13.85%), renal insufficiency (11.54%), hyperlipidemia (8.46%).
  • Primary surgical modalities: lesion excision (41.54%), debridement (34.62%), vacuum sealing drainage (23.08%).
  • Wound healing achieved in 124 cases (95.38%) with a mean healing time of 31.43 days.
  • Postoperative positive microbiological culture rate decreased significantly from 16.15% to 0.77%.
  • Significant reductions in WBC, NE, BUN, uric acid, and creatinine postoperatively.
Interpretation:

Surgery for gouty tophi wounds effectively reduces inflammation, improves infection outcomes, alleviates symptoms, and enhances recovery, particularly when combined with urate-lowering therapy.

Limitations:
  • Retrospective design may introduce bias.
  • Single-center study limits generalizability.
Conclusion:

Gouty tophi wound patients are primarily older males with comorbidities but low bacterial culture rates. Surgical intervention, alongside medical therapy, optimizes patient outcomes.

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