Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease - Summary - MDSpire

Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease

  • By

  • Zuyi Fan

  • Anqi Zhang

  • Yumeng Xi

  • Meng Wang

  • Zhenzhen Fan

  • Zhihui Dong

  • July 3, 2026

  • 0 min

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Objective:

To present a case of a large esophageal schwannoma and highlight the role of spectral CT in its diagnosis and characterization.

Approach:
  • Patient Presentation: A 48-year-old woman with mild dysphagia and an incidentally detected right mediastinal mass.
  • Imaging Techniques: Spectral CT was utilized to assess the characteristics of the esophageal mass and associated lymph nodes.
  • Histopathological Analysis: Post-surgery, histopathology confirmed the diagnosis of schwannoma and reactive lymphoid hyperplasia.
Key Findings:
  • The esophageal mass measured 83 × 63 × 100 mm and displayed heterogeneous enhancement with an intraluminal air crescent sign.
  • Spectral CT provided higher absolute attenuation values compared to conventional CT, aiding in the characterization of the mass and demonstrating spectral differences between the primary mass and lymph nodes.
  • Histopathology revealed a spindle-cell tumor with a prominent peripheral lymphoid cuff, confirming schwannoma and excluding gastrointestinal stromal tumor.
Interpretation:

Limitations:
  • The study is based on a single case, limiting generalizability.
  • Potential for misdiagnosis due to overlapping imaging features with other tumors.
Conclusion:

The case illustrates the utility of spectral CT in diagnosing esophageal schwannoma and highlights the importance of histopathological correlation.

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