To synthesize emerging evidence on prognostic factors in Mycosis Fungoides (MF) and Sézary Syndrome (SS), focusing on traditional and genomic prognostic frameworks.
Approach:
Review of Prognostic Factors: The review outlines established prognostic frameworks and highlights recent genomic advances affecting prognosis in MF and SS.
Key Findings:
Stage remains the most established prognostic factor in MF/SS.
Higher TNMB classification and clinical stage correlate with reduced survival.
Blood stage (B) has been added as a prognostic factor, with recent changes in classification impacting interpretation.
Interpretation:
Integration of traditional and biological prognostic frameworks is discussed as a potential approach for managing MF/SS.
Limitations:
Lack of uniform assessment for circulating disease in early-stage skin disease.
Challenges in full TNMB staging due to biopsy requirements and clonal sequencing.
Conclusion:
Understanding disease- and patient-related prognostic factors is integral for managing MF/SS.
