To characterize the clinicopathological features and therapeutic outcomes of atypical Sweet syndrome (SS) in patients with myelodysplastic syndromes (MDS), highlighting its clinical significance.
Key Findings:
All patients presented with fatigue as the initial symptom of MDS.
Skin lesions were painful erythematous plaques accompanied by fever.
Histopathological findings were consistent with atypical SS.
Resolution of SS was achieved through a dual approach of systemic glucocorticoids and therapy targeting MDS.
Interpretation:
Atypical SS is a significant paraneoplastic dermatosis associated with MDS, necessitating careful evaluation and a dual management strategy to improve patient outcomes.
Limitations:
The study is based on a small cohort of three patients, which may limit the generalizability of findings.
Retrospective design may introduce biases that affect the results.
Conclusion:
Atypical SS presents distinctive features in MDS patients and necessitates integrated management to address both the hematologic condition and the cutaneous manifestations.
