MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty - Summary - MDSpire

MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty

  • By

  • Anna-Mariia Shulhai

  • Michele Maddalo

  • Maddalena Petraroli

  • Francesca Ormitti

  • Benedetta Piccolo

  • Emanuela Claudia Turco

  • Nicola Sverzellati

  • Caterina Ghetti

  • Susanna Esposito

  • Maria Elisabeth Street

  • May 29, 2026

  • 0 min

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Objective:

To investigate radiomic features of the pineal gland associated with puberty onset.

Key Findings:
  • Two radiomic features were identified as predictive of CPP, but they varied between readers and showed poor inter-reader reliability.
  • Radiomic performance was low (ROC-AUC of 0.64 for R1 and 0.59 for R2).
  • The reference model based on pineal cyst features also demonstrated poor performance (ROC-AUC = 0.52).
  • No significant correlations between cyst features and gonadotropin levels were observed.
Interpretation:

Limitations:
  • Small sample size may limit generalizability.
  • Poor inter-reader reliability affects the robustness of findings.
Conclusion:

Radiomic analysis of the pineal gland does not provide relevant diagnostic information for CPP.

Original Source(s)

MRI features and radiomics of the pineal gland in girls do not show significant changes at onset of puberty

  • by Anna-Mariia Shulhai, Michele Maddalo, Maddalena Petraroli, Francesca Ormitti, Benedetta Piccolo, Emanuela Claudia Turco, Nicola Sverzellati, Caterina Ghetti, Susanna Esposito, Maria Elisabeth Street

  • May 29, 2026

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