Cell-dependent antithrombotic effect of tranexamic acid - Summary - MDSpire

Cell-dependent antithrombotic effect of tranexamic acid

  • By

  • Kata Balog Virág

  • Petra Csikós

  • Alexandra Raska

  • Barbara Baráth

  • Kristóf Molnár

  • Natalia Nikolova

  • Kiril Tenekedjiev

  • Krasimir Kolev

  • Nikolett Wohner

  • May 26, 2026

  • 0 min

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Objective:

To determine how cellular elements modulate TXA’s impact on thrombus formation.

Key Findings:
  • TXA reduced the odds of venous thrombus formation by 90%.
  • TXA did not alter thrombus mass once clots formed.
  • VWF: Ag remained unchanged; MCP-1 rise was suppressed by TXA.
  • TXA decreased thrombin generation in whole blood but not in platelet-rich plasma.
  • TXA inhibited leukocyte surface–mediated plasminogen activation within fibrin clots.
  • Tail bleeding was unaffected by TXA.
Interpretation:

Limitations:
Conclusion:

Original Source(s)

Cell-dependent antithrombotic effect of tranexamic acid

  • by Kata Balog Virág, Petra Csikós, Alexandra Raska, Barbara Baráth, Kristóf Molnár, Natalia Nikolova, Kiril Tenekedjiev, Krasimir Kolev, Nikolett Wohner

  • May 26, 2026

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