Association of serum coiled-coil domain containing protein 11 levels with coronary artery disease

To assess the association between circulating levels of coiled coil domain containing protein 11 (CCDC11) and coronary artery disease (CAD).

Median serum CCDC11 levels were significantly elevated in the CAD group compared to controls (20.4 vs. 13.8 ng/mL, P < 0.001).
CCDC11 levels positively correlated with the number of lesioned coronary vessels (P for trend < 0.001).
Logistic regression analysis indicated that CCDC11 was independently correlated with CAD.
The area under the ROC curve (AUC) for CCDC11 in discriminating CAD was 0.71, significantly higher than that for CRP (0.56, P < 0.01).
An optimal CCDC11 cutoff value of 19.37 ng/mL yielded a sensitivity of 53.4% and specificity of 91.6% for CAD discrimination.

Elevated serum levels of CCDC11 are positively associated with both the presence and severity of CAD.

Potential limitations include the study's retrospective nature and the exclusion of patients with acute conditions.

CCDC11 may serve as a novel and clinically valuable biomarker for CAD.