To examine the time-dependent association of systemic glucocorticoid exposure duration and cumulative dose with the risk of adverse events in individuals with atopic dermatitis.
Approach:
Key Findings:
Longer duration of systemic glucocorticoid use was associated with increased risks of adverse events.
Adverse events included mental disorders, gastrointestinal disorders, osteoporosis, hypertension, and diabetes mellitus.
Duration of use showed more robust associations with adverse events than cumulative dose.
Interpretation:
Limitations:
Potential inaccuracies in coding of diseases in SHI data may lead to overestimation or underestimation of disease frequencies.
The observational nature of the study limits causal inferences.
