Objective:

To examine the time-dependent association of systemic glucocorticoid exposure duration and cumulative dose with the risk of adverse events in individuals with atopic dermatitis.

Approach:

Key Findings:

• Longer duration of systemic glucocorticoid use was associated with increased risks of adverse events.
• Adverse events included mental disorders, gastrointestinal disorders, osteoporosis, hypertension, and diabetes mellitus.
• Duration of use showed more robust associations with adverse events than cumulative dose.

Interpretation:

Limitations:

• Potential inaccuracies in coding of diseases in SHI data may lead to overestimation or underestimation of disease frequencies.
• The observational nature of the study limits causal inferences.

Conclusion:

Source

Based on findings from:

Duration-Dependent Adverse Events of Systemic Glucocorticosteroids in Atopic Dermatitis: A Nationwide Claims Cohort Study

Theresa Klinger, Katharina Müller, Ricarda Graf, Matthias Augustin, Kristina Hagenström. Dermatology And Therapy, 2026.

https://link.springer.com/article/10.1007/s13555-026-01829-4

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