Objective:

To investigate the association between red blood cell (RBC) transfusion and the development of bronchopulmonary dysplasia (BPD) in preterm infants.

Approach:

Key Findings:

• RBC transfusions are associated with an increased risk of BPD in preterm infants.
• The timing of the first transfusion has a nonlinear relationship with BPD development.
• The study accounted for potential confounding factors and employed multiple modelling approaches.

Interpretation:

Limitations:

• Single-centre study may limit generalizability.
• Retrospective design may introduce bias.
• Potential unmeasured confounding factors.

Conclusion:

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