Antibiotic prophylaxis in stone surgery: a systematic review of the literature - Summary - MDSpire

Antibiotic prophylaxis in stone surgery: a systematic review of the literature

  • By

  • Filippo Gavi

  • Mauro Ragonese

  • Daniele Fettucciari

  • Maria Chiara Sighinolfi

  • Filippo Turri

  • Enrico Panio

  • Stefano Moretto

  • Giovanni Balocchi

  • Domenico Maria Sanesi

  • Filippo Marino

  • Alessandra Francocci

  • Pierluigi Russo

  • Nazario Foschi

  • Francesco Pinto

  • Emilio Sacco

  • Bernardo Rocco

  • March 3, 2025

  • 0 min

Share

Objective:

To evaluate the effectiveness of preoperative antibiotic prophylaxis in preventing postoperative urinary tract infections (UTIs) in patients undergoing various types of stone surgery, including URS, RIRS, and PNL.

Key Findings:
  • Postoperative sepsis rates following RIRS range from 0.2% to 17.8%, indicating a significant risk of infection.
  • PNL complications include fever in 10.8% and sepsis in 0.5% of cases, highlighting the need for effective prophylaxis.
  • Antibiotic prophylaxis is recommended for URS (weak strength) and strongly recommended for PNL, suggesting a need for tailored approaches.
Interpretation:

The review highlights the importance of antibiotic prophylaxis in reducing infection risks associated with stone surgery, particularly for PNL and URS, which could inform clinical guidelines.

Limitations:
  • Variability in study quality and risk of bias, including differences in study design and patient populations, may affect the reliability of the findings.
Conclusion:

Antibiotic prophylaxis appears beneficial in reducing postoperative infections in stone surgery, particularly for PNL, warranting further investigation into optimal regimens and their implementation in clinical practice.

Original Source(s)

Antibiotic prophylaxis in stone surgery: a systematic review of the literature

  • by Filippo Gavi, Mauro Ragonese, Daniele Fettucciari, Maria Chiara Sighinolfi, Filippo Turri, Enrico Panio, Stefano Moretto, Giovanni Balocchi, Domenico Maria Sanesi, Filippo Marino, Alessandra Francocci, Pierluigi Russo, Nazario Foschi, Francesco Pinto, Emilio Sacco, Bernardo Rocco

  • March 3, 2025

Related Content

Suction mini-percutaneous nephrolithotomy versus standard percutaneous nephrolithotomy for the management of 2–4 cm kidney stones: study protocol for an international, multicenter, parallel-group, noninferiority, randomized controlled trial

Post-surgical outcomes in transgender women: a prospective analysis of sexual function and health-related quality of life

Efficacy and safety of bilateral same session flexible ureteroscopy using flexible and navigable suction ureteral access sheath (FANS) versus conventional access sheath: a prospective randomized comparative study