A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort - Summary - MDSpire

A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort

  • By

  • Yang Xu

  • Pengfei He

  • Xue Kang

  • Peihui Liu

  • Changming Xu

  • May 29, 2026

  • 0 min

Share

Objective:

To evaluate associations between serum vitamin-related markers and 3-month functional outcomes in acute ischemic stroke (AIS) patients and to develop a nomogram for individualized risk prediction.

Key Findings:
  • The nomogram demonstrated good discrimination with AUC values of 0.878 in the training set and 0.880 in the test set for predicting poor outcomes.
Interpretation:

Remove this section.

Limitations:
  • Single-center study with internal validation only.
  • Requires external multicenter validation and prospective evaluation before routine clinical use.
Conclusion:

Revise to state that the model is preliminary and requires further validation without implying clinical impact.

Original Source(s)

A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort

  • by Yang Xu, Pengfei He, Xue Kang, Peihui Liu, Changming Xu

  • May 29, 2026

Related Content

Acceptability of Technologies to Support Early Dementia Detection: Qualitative Study With the Boston University Alzheimer’s Disease Center Cohort

Not All Poststroke Cognitive Patterns Plateau

Researchers identify divergent recovery, persistence, and decline patterns across cognitive domains following stroke.

Intravenous thrombolysis for acute ischemic stroke in the extended time window of 4.5–24 h: a systematic review and network meta-analysis of randomized controlled trials