Polyfunctional antibody signature defines protection in Andes hantavirus survival

By
Felipe Bravo
Tybbysay P. Salinas
Camila Kossack
Jorge T. Gonzalez
Israel Giacaman
Claudio Quevedo
Sebastián Fuller
Farides Saavedra
Claudio Aguilera-Pérez
Felipe Aguilera
Raúl Riquelme
María Luisa Rioseco
Mario Calvo
Raymond A. Alvarez
Juan Miguel Pascale
Blas Armién
Maritza Navarrete
Jose Luis Garrido
Maria Ines Barria
June 5, 2026
0 min

Frontiers In Immunology

Objective:

To explore the contribution of Fc-mediated effector functions of antibodies in the immune response to Andes orthohantavirus (ANDV) and their association with protection in hantavirus cardiopulmonary syndrome (HCPS) survivors.

Key Findings:

Moderate disease patients exhibited higher IgG levels against Gn and stronger Fc-mediated effector functions compared to severe cases.
Survivors showed elevated IgG and IgM responses against Gn, with polyfunctional non-neutralizing IgG activities persisting for years post-infection.
Fc effector functions were identified as important correlates of protection against ANDV.

Interpretation:

Remove unsupported conclusions and rephrase to reflect findings without editorializing.

Limitations:

The study does not quantify the relative contributions of neutralizing versus non-neutralizing antibody functions.
The extent of Fc-mediated functions' influence on clinical outcomes in HCPS remains poorly defined.