The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy - Summary - MDSpire

The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy

  • By

  • Joyce Karoline Silva

  • Lucas Neves de Farias

  • Tainã Lago

  • Luciana dos Santos Cardoso

  • Ricardo Khouri

  • Paulo Roberto Machado

  • Léa Cristina Castellucci

  • June 1, 2026

  • 0 min

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Objective:

To evaluate the potential of the S. mansoni (Sm29) antigen in regulating the immune response in leprosy through a transcriptome study across clinical reactional forms.

Key Findings:
  • The Sm29 antigen modulated immune response pathways in leprosy, particularly in reactional forms, with a more pronounced effect in RR.
  • In RR, Sm29 increased IL10 levels and modulated CSF2, while in ENL, it affected IL1B and FN1 genes related to various chemokines and cytokines.
  • The top expressed genes in RR were less expressed in ENL, indicating a differential response to Sm29.
Interpretation:

Limitations:
  • Small sample size of 12 patients may limit generalizability.
  • Study focused on specific clinical forms and may not represent all leprosy patients.
Conclusion:

Original Source(s)

The Sm29 antigen differentially shapes transcriptomic and regulatory landscapes across reactional forms of leprosy

  • by Joyce Karoline Silva, Lucas Neves de Farias, Tainã Lago, Luciana dos Santos Cardoso, Ricardo Khouri, Paulo Roberto Machado, Léa Cristina Castellucci

  • June 1, 2026

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