Sympathetic ophthalmia induced by vitrectomy for endogenous fungal endophthalmitis: a case report and literature review - Summary - MDSpire

Sympathetic ophthalmia induced by vitrectomy for endogenous fungal endophthalmitis: a case report and literature review

  • By

  • Xiao-Yan Zhang

  • Jie Huang

  • Yan-E. Gao

  • Jiao Li

  • Ying Wen

  • July 7, 2026

  • 0 min

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Objective:

To report a case of sympathetic ophthalmia (SO) following vitrectomy for endogenous fungal endophthalmitis caused by Aspergillus flavus and to review existing literature on this condition.

Approach:
  • Case Report: A 22-year-old man with a history of fungal endophthalmitis underwent two vitrectomy procedures for treatment and subsequently developed SO in the contralateral eye.
  • Diagnosis and Treatment: Diagnosis of SO was confirmed through multimodal imaging, and treatment with prednisone and adalimumab led to stabilization of the patient's condition.
Key Findings:
  • Sympathetic ophthalmia can develop after vitrectomy for fungal endophthalmitis, challenging the belief that such infections prevent SO.
  • The patient exhibited decreased visual acuity and imaging findings characteristic of SO.
  • Immunosuppressive therapy was essential for managing the patient's condition.
Interpretation:

This case illustrates the challenges in diagnosing and treating sympathetic ophthalmia following intraocular surgery for infectious conditions.

Limitations:
  • The rarity of sympathetic ophthalmia following endogenous fungal endophthalmitis limits the applicability of these findings.
  • This report presents only one case, which may not reflect broader trends.
Conclusion:

Timely diagnosis and treatment strategies are critical for managing sympathetic ophthalmia in the context of fungal endophthalmitis.

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