To investigate whether LRG1 is an independent risk factor for complex coronary lesions and to explore if a combined model with LDL-C could improve predictive performance.
Key Findings:
Significant overexpression of LRG1 in AMI patients compared to non-AMI patients.
Higher serum LRG1 concentrations in individuals with SYNTAX Scores ≥ 23 compared to those with Scores < 23 (P < 0.001).
LRG1 and LDL-C identified as independent predictors of elevated SYNTAX Score ≥ 23.
Logistic regression model showed moderate discriminatory ability (AUC = 0.771) and excellent calibration (P = 0.416).
Interpretation:
Limitations:
Single-center observational study may limit generalizability.
Retrospective design and reliance on de-identified samples.
Conclusion:
Preliminary evidence suggests that serum LRG1 could be a useful biomarker for assessing complex coronary anatomy prior to angiography.
