Chronic Cough Despite Normal Workup

Researchers describe diagnostic evaluation and management considerations when standard testing fails to identify the cause of persistent cough.

By
Kathryn Wighton
February 13, 2026
2 min

Conexiant

Objective:

To highlight the diagnosis and management of cough-predominant laryngeal hypersensitivity syndrome in a patient with unexplained chronic cough.

Approach:

Key Findings:

Normal routine investigations can mask laryngeal hypersensitivity syndrome.
Flexible bronchoscopy is crucial for diagnosing exaggerated laryngeal sensitivity.
Symptoms include chronic cough, throat irritation, and globus sensation.

Interpretation:

Laryngeal hypersensitivity syndrome is often overlooked due to normal findings in standard tests, necessitating targeted evaluations for accurate diagnosis.

Limitations:

The study is based on a single patient case, limiting generalizability.
Lack of long-term follow-up data on management outcomes.

Conclusion:

This case emphasizes the need to consider laryngeal hypersensitivity syndrome in patients with chronic cough when standard investigations yield no results.