Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes - Summary - MDSpire
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Dynamic changes of Kisspeptin during controlled ovarian hyperstimulation (COH) in polycystic ovary syndrome patients and its correlation with COH outcomes
To explore dynamic changes in serum and follicular fluid Kisspeptin levels during COH in PCOS patients and analyze their correlation with COH and pregnancy outcomes, highlighting Kisspeptin's potential as a predictive biomarker.
Key Findings:
Serum and FF Kisspeptin levels were significantly higher in the PCOS group at all time points (P<0.001).
Kisspeptin levels on dOPU were significantly elevated compared to dGn (P<0.001).
Positive correlations were found between Kisspeptin levels and AFC, AMH, E2 on dhCG, number of retrieved oocytes, and available embryos.
Negative correlation with top-quality embryo (TQE) rate (P<0.01).
PCOS group had lower TQE rate, cumulative pregnancy rate (40.00% vs. 60.00%, P = 0.046), and live birth rate (8.54% vs. 35.06%, P = 0.014) compared to controls.
Serum Kisspeptin levels on dOPU had predictive value for pregnancy outcomes (AUC = 0.655, 95% CI: 0.547–0.763).
Interpretation:
Kisspeptin may play a role in ovarian hyperresponse and asynchronous follicular development in PCOS, indicating its potential as a predictive biomarker for pregnancy outcomes, which could inform clinical practices.
Limitations:
Limited sample size may affect the generalizability of the findings, particularly in diverse PCOS populations.
The study focused only on IVF-ET patients, which may not represent all PCOS patients, limiting the applicability of the results.
Conclusion:
Kisspeptin levels are associated with COH outcomes in PCOS, providing insights into reproductive dysfunction mechanisms and potential predictive models for treatment, which could enhance individualized patient care.
